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Epidemiology faces its limits--old article very worthwhile knowing about
Posted: Thu Aug 02, 2012 6:08 pm
by Benko
If you have not seen it, this ancient article from 1995 is still very worthwhile reading
Epidemiology faces its limits, By Gary Taubes
http://geography.ssc.uwo.ca/faculty/bax ... e_1995.pdf
since it explain that limits of what one can conclude e.g. most epidiomologists would not take seriously a single study reporting that something increased the risk of cancer unless it increased it by a least a factor of 3 i.e. 300%. Even then experts would be skeptical unless the study was very large and well done.
So when you hear of a single study that increases the odds of something bad happening by 1.5, or increased the odds by 50%...
Re: Epidemiology faces its limits--old article very worthwhile knowing about
Posted: Thu Aug 02, 2012 6:15 pm
by Xan
His great recent article about that "eating meat causes premature death" study quotes the paper you just linked to. (I think this article is worth reading in full, as is Good Calories, Bad Calories.)
Moreover, this meat-eating association with disease is a tiny association. Tiny. It’s not the 20-fold increased risk of lung cancer that pack-a-day smokers have compared to non-smokers. It’s a 0.2-fold increased risk — 1/100th the size. So with lung cancer we could buy as a society the observation that cigarettes cause lung cancer because it was and remains virtually impossible to imagine what other factor could explain an association so huge and dramatic. Experiments didn’t need to be done to test the hypothesis because, well, the signal was just so big that the epidemiologists of the time could safely believe it was real. And then experiments were, in effect, done anyway. People quit smoking and lung cancer rates came down, or at least I assume they did. (If not, we’re in trouble here.) When I first wrote about the pseudoscience of epidemiology in Science back in 1995, “Epidemiology Faces It’s Limits”?, I noted that very few epidemiologists would ever take seriously an association smaller than a 3- or 4-fold increase in risk. These Harvard people are discussing, and getting an extraordinary amount of media attention, over a 0.2-fold increased risk. (Horn-blowing alert: my Science article has since been cited by over 400 articles in the peer-reviewed medical literature, according to Thomson Reuter’s Web of Knowledge.)
http://garytaubes.com/2012/03/science-p ... -and-meat/
Re: Epidemiology faces its limits--old article very worthwhile knowing about
Posted: Thu Aug 02, 2012 7:57 pm
by Benko
"Good Calories, Bad Calories" I have not read, and can not speak to, but some very smart people (in the area of diet, etc) trash Taubes based on this and his more recent books on diet so I will withhold judgement. If you look up Good calories, bad calories on Amazon, and read the 1 star reviews, the first one that come up ("Extremely misleading. Not a panacea for Western diseases") may give you a clue of the opposite point of view.