All Things Permanent Health

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MachineGhost
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All Things Permanent Health

Post by MachineGhost » Wed Jul 13, 2016 11:27 pm

Wow, could the infamous Tricky Dick's reputation possibly get any worse? YES!!! The guy is definitely jostling for the crown after FDR.
To kill off cancer, the US needs a second National Cancer Act

Decades after the US launched a huge initiative against the disease, new legislation is needed to cut bureaucracy and finish the job

By Vincent DeVita

SOME people believe that a lack of scientific progress is why we have not won the war on cancer. They point to the billions of dollars poured into research since the US government took on the disease via the 1971 National Cancer Act. And yet here we are, stuck in the trenches, they say.

The naysayers are wrong. Victory may be elusive, but not because the science is holding it back. I have seen the war from many angles: as researcher, clinician and director at the National Cancer Institute (NCI) in Bethesda, Maryland, as physician-in-chief at the Memorial Sloan Kettering Cancer Center in New York City, as director of Yale University’s Cancer Center, as president of the American Cancer Society and, most recently, as a patient.

No, the real impediment in the war is the regulatory environment and an outdated infrastructure for it, created well before we knew much about the disease.

As a result, outdated beliefs persist; bureaucratic battles erupt among physicians and medical groups; and the Food and Drug Administration (FDA) has yet to catch up with innovations in cancer drug development.


The National Cancer Act gave us the resources to amass the knowledge we now have. It also freed the research community to use its knowledge and tools efficiently, unencumbered by agency bureaucracies.

But it wasn’t perfect. The draft act had called for the NCI, rather than the FDA, to approve cancer drugs as the institute better understood the issues, both scientific and practical. That didn’t happen, and the FDA stands accused of being a roadblock for patients awaiting new drugs.

Its superior understanding also won the NCI independence from the rest of the National Institutes of Health, but it has allowed this independence to be eaten away. The act also established cancer centres in universities, but they got embroiled in academic politics and fundraising battles.

So I say it is time for a new act, one that combines additional resources with the flexibility to untangle strangling regulation. It should allow NCI-funded centres to operate as independent NCI replicas, where research is done in concert with treatment. It would shift authority for early clinical trials from the FDA to the cancer centres. This would get new discoveries to patients much quicker. Finally, we need a cancer czar with control over the programme’s budget.

If we do all this, we will soon see the end of cancer as a major public health issue. We have the critical mass of scientific knowledge; we need only to get around stifling regulations. The American people, who funded this war, deserve to see a victory.

This article appeared in print under the headline “Cancer’s final act?”

Vincent DeVita is a professor of medicine, epidemiology and public health at Yale School of Medicine, and co-author of The Death of Cancer (Sarah Crichton Books)

Magazine issue 3046, published 7 November 2015

https://www.newscientist.com/article/mg ... ancer-act/
"All generous minds have a horror of what are commonly called 'Facts'. They are the brute beasts of the intellectual domain." -- Thomas Hobbes

Disclaimer: I am not a broker, dealer, investment advisor, physician, theologian or prophet.  I should not be considered as legally permitted to render such advice!
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Maddy
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Re: All Things Permanent Health

Post by Maddy » Thu Jul 14, 2016 8:41 am

Darn it; from the title of this thread, I thought it was going to focus on a formula for getting and staying in great health. I've been wishing for a broader version of the Permanent Supplement thread.
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Re: All Things Permanent Health

Post by MachineGhost » Thu Jul 14, 2016 9:54 am

Maddy wrote:Darn it; from the title of this thread, I thought it was going to focus on a formula for getting and staying in great health. I've been wishing for a broader version of the Permanent Supplement thread.
It's a process. We covered The Permanent Health Diet or was it The Perfect Health Diet a few years ago, so that was sort of an extension to the Supplement thread. I'm not a great writer otherwise I would have written a FAQ long before now.
"All generous minds have a horror of what are commonly called 'Facts'. They are the brute beasts of the intellectual domain." -- Thomas Hobbes

Disclaimer: I am not a broker, dealer, investment advisor, physician, theologian or prophet.  I should not be considered as legally permitted to render such advice!
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Re: All Things Permanent Health

Post by Maddy » Thu Jul 14, 2016 12:49 pm

Speaking of cancer research, there are some very interesting studies going on regarding the potential for treating cancer (as well as a number of metabolic diseases) with a ketogenic diet. One line of research that I found particularly intriguing is that being pursued by a Dr. D'Angostino at the University of South Florida, a mainstream institution. In a nutshell, this researcher has found that while cancer cells thive on glucose (think PET scans, which utilize radioactively labeled glucose as a tracer), they cannot effectively utilize ketone bodies as a source of energy. Of course, things that look promising in vitro often do not pan out in vivo, but I thought this was interesting nonetheless--particularly in light of the fact that the ketogenic diet is being used clinically, apparently with some success, in connection with some other serious illnesses (epilepsy, ALS).

Here's the link to an interview with Dr. D'Angostino. https://www.youtube.com/watch?v=UjPgK7gWJeMI Warning: It's lengthy, and the interviewer is that kooky Dr. Mercola, but if you can get past Dr. Mercola's introduction, it's smooth sailing from then on.

If this video has been posted to this forum before, I apologize. I don't remember where I saw it originally.
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Re: All Things Permanent Health

Post by MachineGhost » Thu Jul 14, 2016 10:00 pm

This is really infuriating and I don't recall seeing any hyperbolism in the lamestream media about it (but then again, I rarely pay attention to it anymore).
In 2015, Darcy Olsen, the president and CEO of the Goldwater Institute, a national policy and litigation organization that has changed more than 200 laws nationwide, released a book titled The Right to Try: How the Federal Government Prevents Americans from Getting the Lifesaving Treatments They Need. Throughout the book, Olsen states that the FDA’s approval process for new lifesaving medications is needlessly costing tens of thousands of American lives each year. She reveals disturbing statistics that underscore the depth of this worsening problem.

“The FDA,” says Olsen, “takes as long as 15 years to bring a new medicine to market and Americans are waiting 60% longer for the FDA to approve lifesaving devices than they did just seven years ago. Instead of speeding medical innovation, the FDA is slowing it down—demanding more data, more tests, and more procedures on more subjects before it will approve a drug.”

The book begins with the story of Ted Harada, a father of three who was diagnosed with amyotrophic lateral sclerosis (ALS) at age 38. Amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease, is 100% fatal, with death occurring within two to five years.

But Harada was fortunate. In 2011, he underwent experimental stem cell surgery at Emory University in Atlanta, Georgia, that reversed his symptoms completely. A second surgery was done in 2012—and two months later, Harada had recovered enough to participate in an ALS fundraising walk.

Then the FDA intervened and decided Harada could not have any further surgeries. He is also unable to undergo surgery outside of the study because the treatment has not yet been approved by the FDA. This lifesaving surgery is also unavailable to the nearly 24,000 people who have died since the clinical trials began. Every 90 minutes, someone with ALS dies.

In an interview with Darcy Olsen, Harada posed the question: “If I have twice shown the surgery is safe and effective, why should I have to ask the FDA for permission to do it? If I have a doctor and a drug company willing to provide this to me, and I obviously have informed consent, why should I ever have to be in a position to go hat in hand to the FDA asking for their permission for something that has been shown to work for me twice? Why should my life rest in their hands?”

Full Interview: http://www.lifeextension.com/Magazine/2 ... ry/Page-01
"All generous minds have a horror of what are commonly called 'Facts'. They are the brute beasts of the intellectual domain." -- Thomas Hobbes

Disclaimer: I am not a broker, dealer, investment advisor, physician, theologian or prophet.  I should not be considered as legally permitted to render such advice!
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Re: All Things Permanent Health

Post by MachineGhost » Fri Jul 15, 2016 8:39 pm

Here's a free 165-page book, Stop Renting Your Health -- Own It: A Three Step Approach, from a still active guy past 65 who still beats professional athletes in their 20's. I have not read it yet, but he advocates a Mediterranean diet, high intensity interval training, supplements, etc. so it sounds kosher. He also hasn't eaten any read meat in 35 years which is rather interesting.

http://www.mackieshilstone.com/wp-conte ... -05515.pdf
"All generous minds have a horror of what are commonly called 'Facts'. They are the brute beasts of the intellectual domain." -- Thomas Hobbes

Disclaimer: I am not a broker, dealer, investment advisor, physician, theologian or prophet.  I should not be considered as legally permitted to render such advice!
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Re: All Things Permanent Health

Post by MachineGhost » Sat Jul 16, 2016 6:41 am

Eating only breakfast and lunch reduced body weight, HFC, fasting plasma glucose, C-peptide and glucagon, and increased OGIS, more than the same caloric restriction split into six meals. These results suggest that, for type 2 diabetic patients on a hypoenergetic diet, eating larger breakfasts and lunches may be more beneficial than six smaller meals during the day.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079942/
Do not run more than 5-10 minutes a day!

Image
http://content.onlinejacc.org/article.a ... ID=1891600
"All generous minds have a horror of what are commonly called 'Facts'. They are the brute beasts of the intellectual domain." -- Thomas Hobbes

Disclaimer: I am not a broker, dealer, investment advisor, physician, theologian or prophet.  I should not be considered as legally permitted to render such advice!
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Re: All Things Permanent Health

Post by MachineGhost » Sun Jul 17, 2016 3:29 pm

Another good one from John Oliver... this one is about bullshit masquerading as science. ;D

https://www.youtube.com/watch?v=0Rnq1NpHdmw
Last edited by MachineGhost on Sun Jul 17, 2016 3:45 pm, edited 1 time in total.
"All generous minds have a horror of what are commonly called 'Facts'. They are the brute beasts of the intellectual domain." -- Thomas Hobbes

Disclaimer: I am not a broker, dealer, investment advisor, physician, theologian or prophet.  I should not be considered as legally permitted to render such advice!
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Re: All Things Permanent Health

Post by Reub » Sun Jul 17, 2016 3:36 pm

MachineGhost wrote:
Eating only breakfast and lunch reduced body weight, HFC, fasting plasma glucose, C-peptide and glucagon, and increased OGIS, more than the same caloric restriction split into six meals. These results suggest that, for type 2 diabetic patients on a hypoenergetic diet, eating larger breakfasts and lunches may be more beneficial than six smaller meals during the day.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079942/
Do not run more than 5-10 minutes a day!

Image
http://content.onlinejacc.org/article.a ... ID=1891600
This looks like a great endorsement for some limited running, though. It reduces overall mortality and cardiovascular mortality by a significant amount.
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Re: All Things Permanent Health

Post by Reub » Sun Jul 17, 2016 4:08 pm

Reub wrote:
MachineGhost wrote:
Eating only breakfast and lunch reduced body weight, HFC, fasting plasma glucose, C-peptide and glucagon, and increased OGIS, more than the same caloric restriction split into six meals. These results suggest that, for type 2 diabetic patients on a hypoenergetic diet, eating larger breakfasts and lunches may be more beneficial than six smaller meals during the day.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079942/
Do not run more than 5-10 minutes a day!

Image
http://content.onlinejacc.org/article.a ... ID=1891600
This looks like a great endorsement for some limited running, though. It reduces overall mortality and cardiovascular mortality by a significant amount.
This from the study cited:

"Compared with nonrunners, runners had 30% and 45% lower adjusted risks of all-cause and cardiovascular mortality, respectively, with a 3-year life expectancy benefit. In dose-response analyses, the mortality benefits in runners were similar across quintiles of running time, distance, frequency, amount, and speed, compared with nonrunners. Weekly running even <51 min, <6 miles, 1 to 2 times, <506 metabolic equivalent-minutes, or <6 miles/h was sufficient to reduce risk of mortality, compared with not running. In the analyses of change in running behaviors and mortality, persistent runners had the most significant benefits, with 29% and 50% lower risks of all-cause and cardiovascular mortality, respectively, compared with never-runners.

Conclusions Running, even 5 to 10 min/day and at slow speeds <6 miles/h, is associated with markedly reduced risks of death from all causes and cardiovascular disease. This study may motivate healthy but sedentary individuals to begin and continue running for substantial and attainable mortality benefits."

So are all of you going to lace on your running shoes right now?
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Re: All Things Permanent Health

Post by MachineGhost » Sun Jul 17, 2016 4:57 pm

Reub wrote:So are all of you going to lace on your running shoes right now?
I "ski" in place for 20 minutes a day, 5x a week to target the optimal mortality reduction. I'm a fan of MEMR: minimum effort, maximum results.

If you don't like running, you can do the HIIT: 2 minutes slow, 30 seconds all out, repeat three times, for a total of 10 minutes a day. I posted that study somehwere else.
Last edited by MachineGhost on Sun Jul 17, 2016 9:58 pm, edited 1 time in total.
"All generous minds have a horror of what are commonly called 'Facts'. They are the brute beasts of the intellectual domain." -- Thomas Hobbes

Disclaimer: I am not a broker, dealer, investment advisor, physician, theologian or prophet.  I should not be considered as legally permitted to render such advice!
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Re: All Things Permanent Health

Post by MachineGhost » Sun Jul 17, 2016 9:56 pm

Got in my latest gut analysis. Despite taking a wide variety of probiotics and prebiotic fibers every day since the last test about eight months ago, it hasn't done much to improve my gut diversity except from an already ridiculously low 16th percentile to 30th percentile. WTF!! >:(

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"All generous minds have a horror of what are commonly called 'Facts'. They are the brute beasts of the intellectual domain." -- Thomas Hobbes

Disclaimer: I am not a broker, dealer, investment advisor, physician, theologian or prophet.  I should not be considered as legally permitted to render such advice!
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