Statins and Arthritis
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MachineGhost
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Re: Statins and Arthritis
There's a statin-iron connection. Details here: http://gyroscopicinvesting.com/forum/ot ... #msg122487
"All generous minds have a horror of what are commonly called 'Facts'. They are the brute beasts of the intellectual domain." -- Thomas Hobbes
Disclaimer: I am not a broker, dealer, investment advisor, physician, theologian or prophet. I should not be considered as legally permitted to render such advice!
Disclaimer: I am not a broker, dealer, investment advisor, physician, theologian or prophet. I should not be considered as legally permitted to render such advice!
-
MachineGhost
- Executive Member
- Posts: 10054
- Joined: Sat Nov 12, 2011 9:31 am
Re: Statins and Arthritis
[quote=http://www.nytimes.com/2015/06/11/us/pa ... heart.html]“While the preliminary data on both drugs are encouraging, there is no substitute for large randomized clinical trials,” he said. And, he added, the very low LDL levels are so unprecedented, that “it would be cavalier to assume that nothing could possibly go wrong.”
“We’ve not ever done anything like this with drugs before,” Dr. Avorn said.[/quote]
Generally, I'm liking this approach better than statins. From my understanding, instead of targeting the cholesterol production mechanism, it focuses on reducing LDL by degrading it. So in theory, it should lower the LDL particle quantity and not cholesterol per se. A huge red flag is this is a monoclonal antibody of which other derived drugs have caused cancer.
It also looks like berberine already does the job: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781434/
Of course, this is still an intervention that doesn't fix the underlying problem of endothelial dysfunction (which is what allows lipoprotein particles to go into the artery wall and be retained, initiating the inflammation cascade, eventual heart attack and death). However, reducing oxidized LDL by any mechanism will certainly help maintain endothelial integrity.
I'm pretty sure what is going to happen is people will use these new drugs as a crutch-all not to adopt a healthier lifestyle and diet. Why bother when you can just get an injection and no harm done or so they think?
“We’ve not ever done anything like this with drugs before,” Dr. Avorn said.[/quote]
Generally, I'm liking this approach better than statins. From my understanding, instead of targeting the cholesterol production mechanism, it focuses on reducing LDL by degrading it. So in theory, it should lower the LDL particle quantity and not cholesterol per se. A huge red flag is this is a monoclonal antibody of which other derived drugs have caused cancer.
It also looks like berberine already does the job: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781434/
Of course, this is still an intervention that doesn't fix the underlying problem of endothelial dysfunction (which is what allows lipoprotein particles to go into the artery wall and be retained, initiating the inflammation cascade, eventual heart attack and death). However, reducing oxidized LDL by any mechanism will certainly help maintain endothelial integrity.
I'm pretty sure what is going to happen is people will use these new drugs as a crutch-all not to adopt a healthier lifestyle and diet. Why bother when you can just get an injection and no harm done or so they think?
Last edited by MachineGhost on Mon Jun 22, 2015 9:43 am, edited 1 time in total.
"All generous minds have a horror of what are commonly called 'Facts'. They are the brute beasts of the intellectual domain." -- Thomas Hobbes
Disclaimer: I am not a broker, dealer, investment advisor, physician, theologian or prophet. I should not be considered as legally permitted to render such advice!
Disclaimer: I am not a broker, dealer, investment advisor, physician, theologian or prophet. I should not be considered as legally permitted to render such advice!